Efficiency of platelets rich fibrin (PRF) in the treatment of alveolar osteitis and the subsequent bone formation (a randomized controlled clinical study)

Abstract

Alveolar osteitis is the most common post-operative complication after dental extraction, with severe pain as the main complaint of patients. This study aimed to evaluate the effectiveness of platelet-rich fibrin in treating alveolar osteitis. The study scope included pain reduction, clinically assessed tissue healing, and radiographically evaluated socket bone formation. A total of 20 patients presenting with alveolar osteitis were included in the study. Ten of them were treated using Alveogyl as a control group, and 10 were patients treated using platelet-rich fibrin as a study group. The evaluation of pain reduction using the Visual Analogue Scale (VAS), gingival healing using the Landry Healing Index, and bone formation in the socket using standardized periapical x-rays at baseline, 3 months, and 6 months follow-up. Results showed significant relief of pain, resolution of inflammation, and bone formation in both groups. PRF was more effective in promoting healing compared to Alveogyl. The Alveogyl group experienced a better outcome, with complete elimination of pain. Bone formation was equal between the two groups, with a slightly higher density in the PRF group. Both treatment modalities demonstrated exemplary performance in treating alveolar osteitis, as evidenced by pain reduction, resolution of inflammation, and bone formation. Although PRF showed better tissue healing and significantly more bone formation, alveogyl remains faster in pain reduction, which is the primary concern of patients presenting with alveolar osteitis.