Central giant cell multifocal granuloma: a case report
Authors
Giulia Ciciarelli, Ali Jahjah, Jasmin Noudeh Gholami, Luca Gentili, Antonio Capogreco, Filippo Giovannetti, Matteo Nagni
Abstract
Objective:
To present a rare case of synchronous central giant cell granuloma (CGCG) lesions affecting both the maxilla and mandible in a non-syndromic patient without hyperparathyroidism, and to analyze the outcomes of conservative surgical management.
Materials and Methods:
A 67-year-old male patient presented with progressive swelling of the right maxillary region. Clinical examination, radiographic imaging (CT), and histopathological analysis confirmed the diagnosis of CGCG in both the maxilla and the right mandibular angle. Serum levels of parathyroid hormone (PTH), calcium, and phosphate were measured to exclude hyperparathyroidism. The surgical removal of both lesions was performed under general anesthesia, followed by conservative bone curettage.
Results:
Both lesions were enucleated, preserving the surrounding structures. The postoperative course was complicated by delayed mucosal healing and facial ecchymosis, attributed to the patient’s comorbid conditions and anticoagulant therapy. Complete healing occurred after two months. At three-year follow-up, clinical and radiographic assessments showed no signs of recurrence.
Conclusion:
This case highlights an unusual presentation of synchronous CGCGs in the maxilla and mandible without associated systemic or syndromic conditions. Despite the multifocal nature of the lesions and the patient’s compromised systemic health, conservative surgical treatment yielded a positive outcome. These findings support the effectiveness of enucleation and curettage in selected cases and emphasize the importance of multidisciplinary evaluation and follow-up.
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