The aim of the present narrative review was to summarize the main indications of antibiotic prophylaxis in dentistry. A search was performed via the search engines Pubmed, Scopus and Web of Science. All types of articles were included in the study except for those found in the various search engines and publications not related to the topic addressed, which were excluded. With the limitations of this study, antibiotic prophylaxis could play a decisive role in avoiding post-operative infections, especially in more invasive surgeries and in compromised patients. Further clinical studies could be useful to further investigate the role of antibiotic prophylaxis according to individual systemic diseases.