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Vol. 15 No. 2 (2024)
DOI: 10.59987/ads/2024.2.76-84
Articles
2024-07-17

Evaluation of changes in postoperative sequelae in implant surgery after the administration of the association of bromelain and escin: a pilot study

Authors

Tommaso Pizzolante, Leonardo Mancini, Maurizio D’Amario, Paolo Rasicci, Enrico Marchetti

Keywords: Bromelain, Implant Surgery, Implantology, Pain, Inflammation, Oedema, tions

Abstract

The purpose of this pilot study was to evaluate the possible effect of two natural en- zymes, bromelain and escin (test), in the treatment of post-operative sequelae after open flap implant placement in the posterior area compared with painkiller medica- tions (control). Fourteen patients were enrolled and randomly assigned to test and control groups. Bromelain and escin were administered in the test group, and a placebo was admin- istered in the control group. Oedema, pain, and trismus were evaluated at the base- line, 2 and 7 days after surgery. Trismus was assessed using an analogue method; oedema was assessed using analogue and digital methods, while pain was reported using a numerical rating scale (NRS). Descriptive analysis and not paired-test were performed. The analogue data for oedema for the test and control groups was 10.73 ± 0.77 cm and 10.67 ± 0.74 cm (p-value baseline–7 days = 0.1004) at 7 days post-surgery. The digital analysis showed at 7 days post-surgery 0.41 ± 0.24 mm for the test group and 0.56 ± 0.52 mm for the control group (p-value baseline–7 days = 0.3140). Pain (NRS 0–10) was higher for the test group at each time point. Trismus was accentuated in the test group at each time point after the surgery. Statistically significant differences were found for the analogue oedema evaluation between baseline and day 2, for trismus in both baseline and day 2 and baseline and day 7 comparison, and for paracetamol tablets intake at day 2. Further observations of more patients are needed.
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Authors

Tommaso Pizzolante - Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italyy

Leonardo Mancini - Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italyy

Maurizio D’Amario - Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italyy

Paolo Rasicci - Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italyy

Enrico Marchetti - Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italyy

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, provided appropriate credit is given to the original author(s) and source, a link to the license is provided, and any changes made are indicated.

https://creativecommons.org/licenses/by/4.0/

Copyright © 2026 The Author(s).

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How to Cite
Pizzolante, T. ., Mancini, L. ., D’Amario, M. ., Rasicci, P. ., & Marchetti, E. . (2024). Evaluation of changes in postoperative sequelae in implant surgery after the administration of the association of bromelain and escin: a pilot study. Annali Di Stomatologia, 15(2), 76–84. https://doi.org/10.59987/ads/2024.2.76-84

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