Histomorphometric comparison between Bio-oss and Sintlife dental in postextraction bone regeneration: a clinical experimental study
Authors
Sofia Rastelli, Tommaso Pizzolante, Domenico Marcattili, Elisa Sorrentino, Jasmin Gholami Noudeh, Eugenio Ortale, Gianluca Botticelli, Giovanni Falisi, Stefano Mummolo
Abstract
This clinical experimental study aims to compare the histomorphometric outcomes of two biomaterials—Bio-Oss, a bovine bone substitute, and Sintlife Dental, a magnesium-enriched hydroxyapatite—in post-extraction alveolar ridge regeneration. Twenty patients requiring tooth extraction were randomly assigned to either the Test group (Sintlife Dental) or the Control group (Bio-Oss). Using quantitative histology, biopsies were collected approximately six months post-surgery to evaluate new bone formation, residual graft material, and intertrabecular spaces. Results indicated that both biomaterials supported bone regeneration; however, Bio-Oss demonstrated a higher percentage of newly formed bone and greater residual material, aligning with its reputation as the gold standard in bone grafting. Sintlife Dental showed a greater tendency toward resorption and fibrous tissue formation. Patient-specific factors such as anatomical conditions and residual bone volume influenced regenerative outcomes. These findings support the effective use of both materials in clinical practice, with Bio-Oss showing superior performance in this sample. Further research with larger cohorts is ongoing to deepen the understanding of biomaterial-bone interactions.
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